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Development and application of reconfigurable monitoring and diagnostic system oriented to machine tool

Jing Minqing,Li Meng,Liu Heng

Strategic Study of CAE 2013, Volume 15, Issue 1,   Pages 34-38

Abstract:

The "system engine + function component" architecture for the reconfigurable monitoringand diagnostic system is presented.This paper has also developed a series of regular monitoring and diagnostic components for computer numericalThen the monitoring and diagnostic system for specific machine tools, which has been running in

Keywords： monitoring and diagnostic system for machine tool     reconfigurable     system engine     function component    

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Intelligent fault diagnostic system based on RBR for the gearbox of rolling mills

Lixin GAO, Lijuan WU, Yan WANG, Houpei WEI, Hui YE

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 4,   Pages 483-490 doi: 10.1007/s11465-010-0118-6

Abstract: This paper presents an intelligent system that is necessary for diagnostic accuracy and efficiency inA rule-based reseaning (RBR) intelligent diagnostic system has been developed based on many successfuldiagnostic applications.Its application results prove that the usability of the system is good and it will increasingly attain

Keywords： rule-based reasoning     fault diagnosis     intelligent system     gear box    

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The design and implementation of remote intelligent condition monitoring and diagnostic system for wind

Yang Wenguang and Jiang Dongxiang

Strategic Study of CAE 2015, Volume 17, Issue 3,   Pages 24-29

Abstract:

This paper researched the key technology of remote intelligent condition monitoring and diagnosticsystem for wind turbines, and described the development details of a system.The system, adopted the distributed architecture, consisted of four subsystems, which were the data acquisitionAn advanced fuzzy expert system is developed for inference engine, and the vibration fault diagnosisThe effectiveness of the system is verified by diagnosing simulated wind turbine faults.

Keywords： wind turbine     diagnostic system     fuzzy expert system    

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Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 723-735 doi: 10.1007/s11684-021-0905-y

Abstract: Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. At present, no definite ALS biomarkers are available. In this study, exosomes from the plasma of patients with ALS and healthy controls were extracted, and differentially expressed exosomal proteins were compared. Among them, the expression of exosomal coronin-1a (CORO1A) was 5.3-fold higher than that in the controls. CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS mice. CORO1A was also overexpressed in NSC-34 motor neuron-like cells, and apoptosis, oxidative stress, and autophagic protein expression were evaluated. CORO1A overexpression resulted in increased apoptosis and oxidative stress, overactivated autophagy, and hindered the formation of autolysosomes. Moreover, CORO1A activated Ca2+-dependent phosphatase calcineurin, thereby blocking the fusion of autophagosomes and lysosomes. The inhibition of calcineurin activation by cyclosporin A reversed the damaged autolysosomes. In conclusion, the role of CORO1A in ALS pathogenesis was discovered, potentially affecting the disease onset and progression by blocking autophagic flux. Therefore, CORO1A might be a potential biomarker and therapeutic target for ALS.

Keywords： amyotrophic lateral sclerosis     coronin-1a     autophagy     pathogenesis    

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Obesity in China: its characteristics, diagnostic criteria, and implications

Weiping Jia

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 129-133 doi: 10.1007/s11684-015-0387-x

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Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma

LIU Ting, HE Xiangge

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 109-114 doi: 10.1007/s11684-007-0021-7

Abstract: The overall diagnostic capabilities and utility of frequency-doubling technology (FDT) in patients withCriteria for inclusion or exclusion were established according to validity criteria for diagnostic studiespublished by the Cochrane Methods Group on Screening and Diagnostic Tests.The included articles are of good quality and FDT can be a highly efficient diagnostic test for primary

Keywords： inclusion     sensitivity analysis     correction     specificity     appropriate    

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An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 506-509 doi: 10.1007/s11684-013-0294-y

Abstract:

This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in

Keywords： radiation dosage     radiology     radiation protection     radiography/statistics & numerical data    

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Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Yu Liao, Yufei Xiang, Zhiguang Zhou

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 243-247 doi: 10.1007/s11684-012-0201-y

Abstract: Although it has been reported for about 20 years, the diagnostic criteria of this disease remain controversialHere, we aim to review and discuss the diagnostic criteria of latent autoimmune diabetes in adults.

Keywords： LADA     diagnostic criteria     autoantibodies     insulin independence     age of diagnosis    

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treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 827-858 doi: 10.1007/s11684-022-0948-8

Abstract: Infertility is experienced by 8%–12% of adults in their reproductive period globally and has become a prevalent concern. Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapies in regenerative medicine and translational investigation. Remarkable progress has been made in understanding the biology and purpose of stem cells. The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied for their possible use in reproductive medicine, particularly for infertility induced by premature ovarian insufficiency and azoospermia. Accordingly, this study discusses current developments in the use of some kinds of MSCs such as adipose-derived stem cells, bone marrow stromal cells, umbilical cord MSCs, and menstrual blood MSCs. These methods have been used to manage ovarian and uterine disorders, and each technique presents a novel method for the therapy of infertility.

Keywords： infertility     stem cell therapy     mesenchymal stem cells     pluripotent stem cells    

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Real-world fuel consumption of light-duty passenger vehicles using on-board diagnostic (OBD) systems

Xuan Zheng, Sheng Lu, Liuhanzi Yang, Min Yan, Guangyi Xu, Xiaomeng Wu, Lixin Fu, Ye Wu

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 2, doi: 10.1007/s11783-019-1212-6

Abstract: • Fuel consumption (FC) from LDPVs is measured using on-board diagnostic method (OBD). • The FC ofNormally, real-world fuel consumption is measured primarily by a portable emission measurement systemThe on-board diagnostic (OBD) approach, which is flexible and offers high-resolution data collection,Fuel consumption was measured by the OBD and constant-volume sampling system (CVS, a regulatory method

Keywords： Fuel consumption     Light-duty passenger vehicles     On-board diagnostic systems    

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iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic

Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 278-285 doi: 10.1007/s11684-016-0453-z

Abstract:

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. We aimed to find novel molecules as potential biomarkers for the early diagnosis of CRC. A serum-free conditioned medium was successfully collected from three pairs of CRC tissue and adjacent normal tissue. iTRAQ-based quantitative proteomic analysis was applied to compare the differences in secretome between primary CRC mucosa and adjacent normal mucosa. A total of 145 kinds of proteins were identified. Of these proteins, 29 were significantly different between CRC and normal tissue. Tropomyosin 2 β (TPM2) exhibited the most significant differences; as such, this protein was selected for further validation. Quantitative real-time PCR indicated that the mRNA expression of TPM2 significantly decreased in the CRC tissue compared with the paired adjacent normal tissue. Immunohistochemical analysis also confirmed that TPM2 was barely detected at protein levels in the CRC tissue. In summary, this study revealed potential molecules for future biomarker applications and provided an efficient approach for the differential analysis of cancer-associated secretome. TPM2 may be valuable for the early diagnosis of CRC.

Keywords： iTRAQ     secretome     colorectal cancer     TPM2    

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Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal

Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 91-100 doi: 10.1007/s11684-019-0696-6

Abstract: The present study aims to investigate the differential diagnostic role of patients with AcK27-HOXB9 PDACThe determination of ratio between HOXB9 and AcK27-HOXB9 exhibited potential diagnostic value in patients

Keywords： HOXB9     AcK27-HOXB9     PDAC    

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Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 618-625 doi: 10.1007/s11684-018-0620-5

Abstract: nephropathy (non-MN), to explore the clinically differential diagnosis of these two types, and to establish a diagnosticwere independently correlated with MN, and these three parameters were then used to establish the MN diagnosticA receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguishThe established diagnostic model that combined multiple factors shows a potential for broad clinical

Keywords： multiparameter analysis     diagnosis     model     membranous nephropathy    

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Development of an artificial intelligence diagnostic model based on dynamic uncertain causality graph

Yang Jiao, Zhan Zhang, Ting Zhang, Wen Shi, Yan Zhu, Jie Hu, Qin Zhang

Frontiers of Medicine 2020, Volume 14, Issue 4,   Pages 488-497 doi: 10.1007/s11684-020-0762-0

Abstract: The overall diagnostic accuracy rate of the model was 96.5%.In conclusion, the diagnostic accuracy of the AI model is promising and may compensate for the limitation

Keywords： knowledge representation     uncertain     causality     graphical model     artificial intelligence     diagnosis     dyspnea    

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Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism

ZHANG Huilan, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 11-14 doi: 10.1007/s11684-008-0003-4

Abstract: for primary aldosteronism in hypertensive patients, we studied the clinical characteristics and the diagnostic
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Title Author Date Type Operation

Development and application of reconfigurable monitoring and diagnostic system oriented to machine tool

Jing Minqing,Li Meng,Liu Heng

Journal Article

Intelligent fault diagnostic system based on RBR for the gearbox of rolling mills

Lixin GAO, Lijuan WU, Yan WANG, Houpei WEI, Hui YE

Journal Article

The design and implementation of remote intelligent condition monitoring and diagnostic system for wind

Yang Wenguang and Jiang Dongxiang

Journal Article

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

Journal Article

Obesity in China: its characteristics, diagnostic criteria, and implications

Weiping Jia

Journal Article

Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma

LIU Ting, HE Xiangge

Journal Article

An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Journal Article

Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Yu Liao, Yufei Xiang, Zhiguang Zhou

Journal Article

treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic

Journal Article

Real-world fuel consumption of light-duty passenger vehicles using on-board diagnostic (OBD) systems

Xuan Zheng, Sheng Lu, Liuhanzi Yang, Min Yan, Guangyi Xu, Xiaomeng Wu, Lixin Fu, Ye Wu

Journal Article

iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic

Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang

Journal Article

Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal

Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang

Journal Article

Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang

Journal Article

Development of an artificial intelligence diagnostic model based on dynamic uncertain causality graph

Yang Jiao, Zhan Zhang, Ting Zhang, Wen Shi, Yan Zhu, Jie Hu, Qin Zhang

Journal Article

Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism

ZHANG Huilan, WANG Daowen

Journal Article